ESPN College GameDay picks the winners of Week 2’s top games in college football

Sep 6, 2025 - 22:00

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ESPN College GameDay picks the winners of Week 2’s top games in college football

The second full weekend of college football is here, and while Notre Dame is off this Saturday, the crew of ESPN’s College GameDay was still at it.

Despite legendary Lee Corso not being on the set following his final show last week, it didn’t stop to crew of Desmond Howard, Nick Saban, Pat McAfee and Kirk Herbstreit from making their picks for Week 2. They were in Norman, Oklahoma as the Sooners are hosting the Michigan Wolverines, and they brought in guest picker Trae Young, who starred on the on the hardwood for Oklahoma and currently playing the Atlanta Hawks.

Find out below who each of them believe will win the biggest games of Week 2 in college football.

No. 11 Illinois Fighting Illini at Duke Blue Devils

Aug 29, 2025; Champaign, Illinois, USA; Illinois Fighting Illini linebacker Gabe Jacas (17) jumps on teammate Illinois Fighting Illini defensive lineman Eli Coenen (96) after a sack on Western Illinois Leathernecks quarterback Chris Irvin (5) during the first half at Memorial Stadium. Mandatory Credit: Ron Johnson-Imagn Images

Howard - Illinois

Saban - Illinois

McAfee - Illinois

Young - Duke

Herbstreit - Duke

Baylor Bears at No. 17 SMU Mustangs

Aug 30, 2025; Dallas, Texas, USA; Southern Methodist Mustangs wide receiver Jalen Cooper (10) celebrates with his teammates after he scores a touchdown during the game between the Southern Methodist Mustangs and the East Texas A&M Lions at Gerald J. Ford Stadium. Mandatory Credit: Jerome Miron-Imagn Images

Howard - Baylor

Saban - SMU

McAfee - SMU

Young - Baylor

Herbstreit - SMU

Virginia Cavaliers at NC State

Aug 30, 2025; Charlottesville, Virginia, USA; Virginia Cavaliers wide receiver Jahmal Edrine (7) celebrates with Virginia Cavaliers wide receiver Eli Wood (82) after scoring a touchdown against the Coastal Carolina Chanticleers during the second quarter at Scott Stadium. Mandatory Credit: Amber Searls-Imagn Images

Howard - Virginia

Saban - Virginia

McAfee - NC State

Young - Virginia

Herbstreit - NC State

Kansas Jayhawks at Missouri Tigers

Aug 28, 2025; Columbia, Missouri, USA; Missouri Tigers quarterback Beau Pribula (9) celebrates after scoring a touchdown against the Central Arkansas Bears during the second half of the game at Faurot Field at Memorial Stadium. Mandatory Credit: Denny Medley-Imagn Images

Howard - Kansas

Saban - Missouri

McAfee - Kansas

Young - Missouri

Herbstreit - Missouri

No. 12 Arizona State Sun Devils at Mississippi State Bulldogs

Arizona State Sun Devils defensive lineman Anthonie Cooper (96) celebrates his interception against the Northern Arizona Lumberjacks during a football game at Mountain America Stadium in Tempe on Aug. 30, 2025.

Howard - Arizona State

Saban - Arizona State

McAfee - Arizona State

Young - Mississippi State

Herbstreit - Mississippi State

No. 20 Ole Miss Rebels at Kentucky Wildcats

Aug 30, 2025; Oxford, Mississippi, USA; Mississippi Rebels defensive end Da'Shawn Womack (15) reacts after a tackle during the fourth quarter against the Georgia State Panthers at Vaught-Hemingway Stadium. Mandatory Credit: Petre Thomas-Imagn Images

Howard - Ole Miss

Saban - Ole Miss

McAfee - Ole Miss

Young - Kentucky

Herbstreit - Ole Miss

Iowa Hawkeyes at No. 15 Iowa State Cyclones

Iowa State Cyclones' defensive line Vontroy Malone (8), linebacker Cael Brezina (9), and defensive back Drew Surges (29) celebrates after a stop South Dakota during the second quarter in the home game opening at Jack Trice Stadium on August 30, 2025, in Ames, Iowa

Howard - Iowa State

Saban - Iowa State

McAfee - Iowa

Young - Iowa State

Herbstreit - Iowa

No. 15 Michigan Wolverines at No. 18 Oklahoma Sooners

Aug 30, 2025; Ann Arbor, Michigan, USA; Michigan Wolverines edge TJ Guy (4) celebrates a fumble recovery in the first half against the New Mexico Lobos at Michigan Stadium. Mandatory Credit: Rick Osentoski-Imagn Images

Howard - Michigan

Saban - Michigan

McAfee - Oklahoma

Young - Oklahoma

Herbstreit - no pick

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This article originally appeared on Fighting Irish Wire: ESPN’s College GameDay picks the winners during Week 2’s action