Mayweather-Pacquiao 2 fight, odds: Floyd Mayweather opens as small favorite in rematch vs. Manny Pacquiao

It's been more than a decade since Floyd Mathweather Jr. and Manny Pacquiao fought back in 2015 — with Mayweather emerging victorious via unanimous decision — but the two former rivals announced this week that they are set to fight again on Saturday, Sept. 19 at the Sphere in Las Vegas, Nevada. The bout will be broadcast on Netflix.

Not surprisingly, Mayweather — 50-0 in his boxing career — opened as the -175 favorite at BetMGM sportsbooks, with Pacquiao the underdog at +125. Mayweather was up to a -190 favorite (implied probability of 65.5%), as of Tuesday afternoon, with Pacquiao at +140.

Pacquiao retired in 2021, before coming out of retirement to post a draw against Mario Barrios last July. Mayweather retired in 2015 after a win against Andrew Berto, before coming out of retirement in August 2017 to fight Conor McGregor.

The first fight between Mayweather and Pacquiao set a record with a staggering 4.6 million pay-per-view buys, although the fight itself was a little disappointing from an entertainment perspective.

Both fighters will have exhibition matches this year, with Pacquiao facing Ruslan Provodnikov on April 18, while Mayweather appears to be heading towards an April 25 fight against Mike Tyson. 

Mayweather is currently 49 years old, while Pacquiao is 47.